Peds Pharmacology



  • Age specific drug dosing:
  • Warnings:
  • Cautions:
  • Contraindications:

Clarks Rule


Young’s Rule


Pediatric Dose by Surface Area


Factors influencing absorption


Pediatric Absorption


Topical Absorption


Pediatric Distribution


Pediatric Metabolism


Pediatric Excretion

  • Underdeveloped renal function.
  • Water-soluble drugs (penicillin, cephalosporins) show prolonged half-life. GFR, renal plasma flow, and tubular function reach adult values 9-12 months of age.

Side effects

MedicationSide Effects
AcetaminophenHepatic dysfunction
AlcoholAggressive Behavior
Hypertension
AminoglycosidesHearing loss
AnticholinergicsXerostomia (dry mouth)
ChloramphenicolGray-Baby Syndrome
CorticosteroidsAcne
Adrenal insufficiency
Growth suppression
InsulinHypoglycemia
SulfonamideKernicterus
TetracyclinesPermanent discoloration of teeth

Medications


Adenosine

Albuterol

Amiodarone

Atropine

Benadryl

Dexamethasone (Decadron)

Dextrose

Dilaudid

EPI (1:10,000)

Etomidate

Glucagon 

Hydroxocobalamin

Ipratropium (Atrovent)

Ketamine

Morphine

Narcan

Rocuronium

Solumedrol 

Succinylcholine

Versed

Zofran

Expectorants


Guaifenesin

Shock


Defibrillation

Synchronized Cardioversion